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Gravity on operation of the interventions(s) and their value in next form III trials Beside intention-to-treat with pitiless rules requiring order as multiple comparisons, interim analyses Exploratory results suggesting extra questioning of interventions(s) may be warranted Weight on clinical benefit and statistical significance Analyses guided by pre-specified statistical dissection plans Confirmatory results which may change clinical practice Charge Steadily escalating as more untested therapies are being investigated, requiring monitoring involving new technologies (MRI, DARLING) with excessive frequency. Impressive improvements in both PFS and OS bring into the world been shown in [86] in 429 women with optimally debulked status III EOC randomly assigned to intravenous paclitaxel added cisplatin versus a cartel of intravenous paclitaxel supplementary intraperito- neal cisplatin and paclitaxel. 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